My pituitary is deficient in ACTH. I have secondary hypoadrenalism. Only this time around, my adrenal glands *did* respond favorably to the stimulation (which was not the case with my original diagnosis in 2003). My last MRI was in 2006 (at the height of my hypopituitarism) and everything then was structurally sound and probably still is.
While talking over my health schtuff with avalons_tear, I stumbled across this article on Pituitary autoantibodies in patients with hypopituitarism and their relatives
It nails the weirdness of my hypopituitarism to a T. Additionally, there's a genetic link: The presence of pituitary autoantibodies in these patients and their relatives was investigated using the above described immunoblotting method. The clinical features of our patients with hypopituitarism were compared with the clinical data recorded in the literature on patients with lymphocytic hypophysitis.
Six of the 21 (28%) patients with hypopituitarism showed reactivity to an Mr 49 000 pituitary cytosolic protein (Table 1). Sera from 10/35 (28%) family members also reacted with this protein (Table 2). Of the control sera, 3/44 (6·8%) showed Mr 49 000 reactivity. Statistical analysis proved that patients as well as relatives showed Mr 49 000 reactivity in significantly higher frequencies than controls (P<0·05 and P<0·02 respectively).
They also explain why my MRI and CTs have all been clean...
Coexistent autoimmune disease is reported in approximately thirty percent of patients with biopsy-proven lymphocytic hypophysitis. Overall we found a similar prevalence in our study. Interestingly, it was those patients with selective pituitary hormone deficiencies who were more likely to have another autoimmune condition.
The possibility of a hereditary immunological pituitary process causing partial or panhypopituitarism in some patients cannot be excluded.
Oh, and get this... one of the authors, A Lernmark, is (or was) at University of Washington, Seattle.
OH! I FORGOT THE BEST PART!!!
That means I can get a diagnosis in my lifetime!!!